|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
It demonstrated that Tra2β was expressed higher in NSCLC tumor tissues compared with adjacent non-tumor tissues.
|
24952301 |
2014 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overall, these findings suggest that the downregulation of miR-335 in A459 lung cancer cells promoted cell proliferation through upregulation of Tra2β, mediated via activation of the AKT/mTOR signaling pathway, and suggest that miR-335 may have potential as a novel therapeutic target for NSCLC.
|
29161765 |
2018 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Tra2β were preferentially expressed in proliferative compartment of normal human colonic glands and adenocarcinomas, where Ets1 and heat shock factor 1 were also highly expressed.
|
23361474 |
2013 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We proposed here a hypothetic model to illustrate that impaired glucose metabolism in AD brain may increase the expression of splicing protein hnRNP A1 and reduce Tra2β-1, which cause the imbalanced expression of mRAGE and esRAGE.
|
25689357 |
2015 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we demonstrate that TRA2β is regulated by the MYC oncogene, plays a role in metastasis maintenance in vivo, and its levels correlate with breast cancer patient survival.
|
31775037 |
2019 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To analyze the expression levels of TRA2β protein in glioma tissues, we performed immunohistochemical and Western blot analysis on human glioma tissues.
|
26298634 |
2015 |
|
Hepatitis, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also measured messenger RNA levels of SIRT1, SFRS10, and lipin-1β and lipin-1α in liver samples from patients with alcoholic hepatitis and individuals without alcoholic hepatitis (controls).
|
24262277 |
2014 |
|
Spinal Muscular Atrophy
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1.
|
14520560 |
2003 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we demonstrate that miR-335 expression is reduced in non-small cell lung cancer (NSCLC) tumors relative to non-cancerous adjacent tissues, while the expression of Tra2β is increased.
|
29161765 |
2018 |
|
Obesity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our results indicate that reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity.
|
21803291 |
2011 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reverse-transcription quantitative polymerase chain reaction analysis and immunochemistry analysis indicated that the increased expression of Tra2β in LSCC was significantly associated with poor differentiation, lymph node metastasis, and advanced clinical stage.
|
30597574 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The splicing regulators Sam68 and Tra2β increase expression in prostate cancer.
|
28382513 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The splicing regulators Sam68 and Tra2β increase expression in prostate cancer.
|
28382513 |
2017 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, we demonstrate that TRA2β is regulated by the MYC oncogene, plays a role in metastasis maintenance in vivo, and its levels correlate with breast cancer patient survival.
|
31775037 |
2019 |
|
Progressive supranuclear palsy
|
0.300 |
Biomarker
|
disease |
CTD_human |
We also found SRSF2, as well as another tau splicing factor, TRA2B, to be increased in brains of PSP patients.
|
25402454 |
2014 |
|
Ophthalmoplegia, Progressive Supranuclear
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation.
|
25402454 |
2014 |
|
Supranuclear Palsy, Progressive, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Mitochondrial complex 1 inhibition increases 4-repeat isoform tau by SRSF2 upregulation.
|
25402454 |
2014 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Specifically, the upregulation of SRSF4, SRSF6, or TRA2β disrupts acinar morphogenesis and promotes cell proliferation and invasion in MCF-10A cells.
|
31775037 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Moreover, siRNA-TRA2B transfection inhibited the invasion but accelerated apoptosis of EC cells.
|
31452736 |
2019 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The results of the present study demonstrated that knockdown of Tra2β inhibits the proliferation and invasion of LSCC cells, at least partly via inhibiting PI3K/AKT signaling.
|
30597574 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
TRA2B is associated with cancer cell survival and therapeutic sensitivity.
|
28416606 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Transformer-2 protein homolog beta (Tra2β) generally plays an important role in various human cancers, but its role and the underlying mechanisms in laryngeal squamous cell carcinoma (LSCC) remained unknown.
|
30597574 |
2019 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tra2β knockdown caused apoptosis of HCT116 cells.
|
23361474 |
2013 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among the dysregulated genes, the strongly upregulated TRA2B in the tissues and serum from patients with EC was selected for further analysis.
|
31452736 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Finally, we demonstrate that TRA2β is regulated by the MYC oncogene, plays a role in metastasis maintenance in vivo, and its levels correlate with breast cancer patient survival.
|
31775037 |
2019 |